Precision Biotics. Clinically Proven.

We begin with a desired health outcome, not a strain in a freezer. The human microbiome produces and transforms more than 29,000 catalogued compounds, many of which shape human health. So we work backward from health function, to mechanism of action, to the strains that robustly deliver the target metabolite(s) across the beautiful diversity of human microbiomes. 

The microbiome is one of nature's largest untapped libraries. We apply artificial intelligence, machine learning, and whole-genome sequencing to mine that diversity at scale, surfacing the pathways and metabolites tied to a specific health outcome, and screening each candidate's genome for safety and efficacy. This in silico search feeds high-throughput lab screening under gut-like conditions.

Before touching a bench, we pressure-test our top candidates in silico. Proprietary and trained gut simulations — as well as large-scale metabolic models — trained on diverse human microbiomes confirm if a strain can reliably deliver its target metabolite while competing against the hundreds of species it will meet in a real gut. Host-microbiome models then predict how the human body itself responds to each candidate. 

The strongest candidates now advance to in-depth characterization. Before strains advance to clinical testing, we validate them against the specific health endpoint they were selected for — using in vitro models, measuring the target metabolites and other key functional markers under conditions that approximate the human gut. In parallel, a rigorous safety assessment confirms each strain is fit for human use.

Scaling novel living ingredients is often where most biology breaks. We engineer the process for efficacy, formidability, and shelf life, so our partners can build clinical-efficacy doses into real products. Our ingredients are GRAS, Kosher-Parve, allergen-free, SCF certified, and Non-GMO Project Verified.

The final proof point is in the end-consumers. We design and run state-of-the-art randomized, double-blind, placebo-controlled clinical trials in the US to confirm the mechanism of action delivers measurable health outcomes with end-consumers, so when we say 'feel the effect,' we prove it.

Scaling next generation strains takes expertise most manufacturers don't have. We match each strain to a specialized manufacturing partner and lead the scale-up process ourselves, from lab batch to pilot to full commercial volume, managing technology transfer and process validation at every step. It's this scale-up expertise that lets Verb commercialize next-generation biotics other companies can't move past the lab bench. 

The resulting next-generation biotic is now ready to be added into food, beverage, and supplement formulations for humans, pets, and agriculture. Our R&D and marketing teams work with our customers to advise on new formulations, identify market opportunities, and ensure successful market launch.