GABA Probiotic, LP815®

For sustained GABA production in the gut

GABA-Producing Probiotic for Stress, Mood, and Sleep Support

LP815 for Gut-Brain Support

GABA (Gamma-Aminobutyric Acid) is a key inhibitory neurotransmitter that helps regulate the nervous system by slowing excessive neural activity.¹ This calming effect plays a critical role in supporting mood, stress response, and sleep quality.² When GABA levels are low or imbalanced, it can contribute to heightened stress, irritability, and disrupted sleep.³⁻⁵

However, traditional GABA supplements often provide only short-lived effects due to limited bioavailability. LP815, GABA Probiotic, is designed to overcome this limitation by enabling sustained, gut-mediated production of GABA, delivering consistent support for mood, stress, and sleep throughout the day and night.

How does LP815 work?

LP815 works with existing gut microbes to continuously generate GABA. GABA produced in the gut can influence brain function and mood through the gut-brain axis, a bidirectional communication pathway between the gut and central nervous system. 

Image of the gut-brain feedback loop. Neuromodulators, Dysbiosis and Bidirectional signaling.

What is a GABA-producing probiotic?

A GABA-producing probiotic is a functional microbial strain designed to generate gamma-aminobutyric acid (GABA) directly in the gut, enabling microbiome-driven support of the gut-brain axis.

LP815 is differentiated by its ability to provide prolonged, sustained GABA production rather than a short-lived dose. By working with the existing gut microbiota, LP815 continuously generates GABA over time, offering a consistent approach to supporting stress, mood, and sleep.

How LP815 Compares to Standard Probiotics and Oral Supplements

Not all GABA support is created equal. The table below compares how standard probiotics, oral GABA supplements, and LP815 differ in mechanism, duration, and clinical validation.

Standard Probiotic
General microbiome support
Oral GABA Supplement
Exogenous GABA delivery
Verb Biotics
LP815®
GABA-producing probiotic
Mechanism
How GABA is delivered
Supports gut health via colonization; no direct GABA production
Exogenous GABA absorbed (poorly) in GI tract; bypasses the gut microbiome entirely
Produces GABA endogenously within the existing gut microbiome — a GABA factory from within
Duration
Length of effect
Variable, dependent on colonization — often inconsistent across individuals
Short-lived spike: GABA levels peak then decline within 2–4 hours of ingestion
Sustained, stable GABA production from Day 1 through Week 6+ — consistent day and night
Clinical Evidence
Published research
Broad category support; strain-specific outcomes vary widely across products
Limited RCT evidence; bioavailability crossing the gut barrier remains scientifically debated
2 peer-reviewed RCTs published in Nature Scientific Reports and Beneficial Microbes (2025–2026)
Gut-Brain Axis
Targets neurological pathway
Indirect at best; general microbiome support may have downstream mood effects
Not a microbiome-mediated pathway; no gut-brain axis mechanism of action
Purpose-built to modulate the gut-brain axis via endogenous GABA signaling
Dosage Flexibility
Formulator-friendly CFU
Typically 10B–50B CFU required; limits format choices and increases cost per serving
Fixed mg dose; no CFU consideration, but bioavailability limits efficacy at most dosages
Clinically efficacious at just 5B CFU — supports flexible formats and clean stack formulations
Validated Outcomes
Measured, reproducible endpoints
General wellbeing claims; sleep and stress-specific endpoints rarely measured
Some consumer evidence exists; limited RCT data on validated sleep or GAD-7 outcomes
77% improved sleep (ISI score); 151% greater stress reduction vs. placebo (GAD-7)
Demonstrated advantage
Category standard
Notable limitation
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LP815® is a registered trademark of Verb Biotics. Clinical findings referenced from peer-reviewed publications in Beneficial Microbes (2025) and Nature Scientific Reports (2026). For B2B industry use only.

What are the benefits of GABA Probiotic, LP815?2,5, 7-9

Helps reduce feelings of irritability

Promotes a calm mood

Supports healthy stress management

Supports deep restorative sleep

Helps reduce nighttime sweating

 

LP815 Clinical Substantiation

Explore the clinical publications that validate the science behind Verb Biotics' LP815 solution. Our research demonstrates a clean commitment to proven efficacy, measurable outcomes, and a new standard of rigor in microbiome innovation.

Explore the LP815 Clinical Trial Takeaways
Clinical Trial Overviews
Study #1 | Stress & Mood | Beneficial Microbes

Overview: This study assessed the impact of Lactiplantibacillus plantarum LP815 on stress.

Study Design: Randomized, double-blind, placebo-controlled, wearable-device clinical trial in 83 healthy adults with mild to moderate anxiety. The study was conducted over a 7-week period with one week of baseline data followed by 5 billion CFU of LP815 or placebo use for 6 weeks.

Outcomes: 5 billion CFU of LP815 significantly reduced stress in a diverse cohort of adults at 4 weeks and 6 weeks following daily consumption.

Published in Beneficial Microbes, 2025

Read the Study

Study #2 | Sleep | Nature Scientific Reports

Overview: This study evaluated whether Lactiplantibacillus plantarum LP815 could improve sleep quality and elevate GABA levels.

Study Design: Randomized, double-blind, placebo-controlled, wearable-device clinical trial with 139 enrolled healthy adults with at least moderate difficulty falling asleep. Participants were assigned to either a placebo or 5 billion CFU of LP815 daily for 6 weeks. A small sub-cohort provided urinary samples for neurotransmitter analysis, including GABA. 

Outcomes: Participants taking 5 billion CFU of LP815 experienced significant improvement in sleep quality, with 77% achieving a clinically meaningful 4-point reduction compared to 58% on placebo. Time asleep as well as deep sleep duration was significantly greater in the LP815 cohort. A sub-study shows that LP815 may increase systematic GABA levels within the first week. 

Read the Study

Dive Deeper into the Science. Download our LP815 Clinical Substantiation Report.

How does GABA Probiotic (LP815) work?

GABA factory

The ability of LP815 to produce GABA itself can be thought of as enabling a GABA factory in the gut. This localized, sustained production supports more consistent modulation of mood, stress response, and nervous system signaling

GI performance

LP815 is derived from a natural Lactiplantibacillus plantarum strain that survives the harsh conditions of the gut to produce GABA.

Prolonged release

Unlike traditional GABA supplements which deliver a bolus dose of GABA resulting in an immediate but transient spike of GABA levels that is gone in a few hours, LP815 offers a consistent and prolonged time release of GABA, and has been studied and evaluated for its ability to provide extended and consistent stress, irritability, and sleep modulation throughout the day and night.

Lower dosage for greater application flexibility

LP815, at a dose of 5 billion CFU, produces 50mg of GABA which is the dose associated with stress, irritability, and sleep benefits. This low CFU dose enables flexibility when formulating. Add LP815 in mood, stress, sleep, and relaxation dietary supplements. Stack with other function-specific biotics for a robust symbiotic offering.

What are the LP815 applications for stress & sleep?

Add LP815 in mood, stress, sleep, and relaxation dietary supplements. LP815 can be added to a variety of supplement formats, including stick packs, capsules, and more!

STRESS & MOOD | SLEEP QUALITY | GUT-BRAIN AXIS | CALMING & RELAXATION

 GRAS  |  Allergen-free | Non-GMO 

GABA Probiotic, LP815 Frequently Asked Questions

What makes LP815 unique?

LP815 is function-first, not CFU-first. Most probiotics focus on colony-forming units and colonization. LP815 is designed to produce GABA, a bioactive that supports the gut-brain axis, delivering consistent, measurable effects instead of variable bacterial counts.

What makes LP815 a 'GABA-producing' probiotic?

LP815 works with existing microbes in the gut to create more GABA, acting as a “GABA factory,” delivering steady GABA to support calm mood, stress resilience, and sleep—unlike quick-spike supplements.

How does LP815 support sleep?

LP815 supports sleep by sustaining GABA levels from day to night. GABA regulates the body’s relaxation response and signals readiness for rest. By maintaining steady GABA via the gut-brain axis, LP815 promotes deeper relaxation and more consistent sleep quality over time, not just short-term effects.

Why does the body need GABA—and how does LP815 help?

Your body relies on steady GABA signaling to maintain calm, stress resilience, and balanced mood. LP815 is a GABA-producing probiotic designed to support this pathway from the gut. By helping maintain consistent GABA availability via the gut-brain axis, LP815 provides dual-action stress and sleep support.

Is LP815 clinically studied?

Yes! LP815 is supported by real-world research and peer-reviewed data on stress, mood, and sleep outcomes. LP815 is GRAS, non-GMO, and allergen-free, meeting the highest standards of safety and quality. Made in the U.S., LP815 is suitable for use in a variety of dietary supplements. Read the study in full here.

Interested in learning more 
about GABA Probiotic, LP815?

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Sources

 

  1. Jewett BE, Sharma S. Physiology, GABA. StatPearls. 2023.
  2. Hepsomali P, Groeger JA, Nishihira J, Scholey A. Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review. Front Neurosci 2020;14:923. https://doi.org/10.3389/fnins.2020.00923.
  3. Yamatsu A, Yamashita Y, Pandharipande T, Maru I, Kim M. Effect of oral γ-aminobutyric acid (GABA) administration on sleep and its absorption in humans. Food science and biotechnology. 2016;25(2):547-551.
  4. Yamatsu A, Yamashita Y, Maru I, Yang J, Tatsuzaki J, Kim M. The Improvement of Sleep by Oral Intake of GABA and Apocynum venetum Leaf Extract. Journal of nutritional science and vitaminology. 2015;61(2):182-187.
  5. Yoto A, Murao S, Motoki M, et al. Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks. Amino acids. 2012;43(3):1331-1337.
  6. Grant, A.D., Erfe, M.C.B., Delebecque, C.J., Keller, D., Zimmerman, N.P., Oliver, P.L., Youssef, B., Moos, J., Luna, V., & Craft, N. (2025). Lactiplantibacillus plantarum Lp815 decreases anxiety in people with mild to moderate anxiety: a direct-to-consumer, randomised, double-blind, placebo-controlled study. Beneficial Microbes, 16(5), 521-532.
  7. Stress in America 2023; a nationwide survey conducted by The Harris Poll on behalf of America Psychological Association among more than 3,000 U.S. adults age 18+. LINK
  8. Abdou AM, Higashiguchi S, Horie K, Kim M, Hatta H, Yokogoshi H. Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans. Biofactors. 2006;26(3):201-8.doi:10.1002/biof.5520260305
  9. Grant, A.D., Erfe, M.C.B., Delebecque, C.J. et al. Lactiplantibacillus plantarum Lp815 improves sleep and increases urinary GABA in a randomized, double-blind, placebo-controlled study of sleep disturbance. Sci Rep 16, 644 (2026).

Disclaimer
This material is provided solely for business-to-business use by qualified industry professionals. It is not designed for consumer-facing communication or distribution.