GABA Probiotic

Supports calming
and relaxation

for prolonged release of GABA

Natural GABA for gut-brain modulation

GABA (Gamma-Aminobutyric Acid) is a major inhibitory neurotransmitter and functional metabolite that plays a key role in signaling the nervous system.1 Studies suggest that GABA’s main mechanism of action is to aid in slowing the stimulation of specific nerve signals in the brain, supporting mood and stress regulation.2 Deficits in GABA levels can lead to a cascade of health outcomes ranging from stress and mood swings to impacts on sleep quality and cognitive function.3-5

GABA Probiotic is designed to deliver a prolonged release of GABA to provide calming and stress support consistently throughout the day and night.*

*Human clinical studies to be completed in 2024

#1 2024

New Year Resolution by US and UK consumers is “Improve my mental health & wellbeing”6

1/4

of US adults rate their stress between 8-10 on a scale of 1-10, up from 19% in 20197

Mechanism of Action

GABA produced in the gut can affect brain function and mood via a bidirectional communication pathway. GABA Probiotic delivers GABA through oral ingestion while working with one’s existing gut microbiota to produce additional GABA.

Prolonged GABA release, Lactiplantibacillus plantarum Lp815™

Lactiplantibacillus plantarum, Lp815™, a proprietary strain of lactic acid bacteria, was isolated for its ability to provide sustained GABA production. By utilizing advanced computational modeling and high-throughput screening, we benchmarked against the top strains in the industry to select a superior GABA
producer.

This bacterial strain is unique for its robust and prolonged production of GABA in the gastrointestinal tract in contrast to traditional GABA supplements, which result in an immediate but transient spike in GABA levels, requiring redosing throughout the day.

Potential Microbiome benefits
of GABA Probiotic2,5, 7-8

Supports a calming mood and feelings of relaxation

Supports a healthy stress response

How GABA Probiotic works

GABA factory

The ability of Lp815™ to produce GABA itself can be thought of as enabling a GABA factory in the gut.

GI performance

GABA Probiotic is derived from a natural Lactiplantibacillus plantarum strain that survives the harsh conditions of the gut to produce GABA.

Prolonged release

Unlike traditional GABA supplements which deliver a bolus dose of GABA resulting in an immediate but transient spike of GABA levels that is gone in a few hours, GABA Probiotic offers a consistent and prolonged time release of GABA, and is being evaluated for its ability to provide extended and consistent calming and stress modulation throughout the day and night.

Lower dosage for greater application flexibility

GABA Probiotic at a dose of 1 billion CFU, produces 100mg of GABA which is the dose associated with stress, mood, sleep, and cognitive benefits.2-5, 7-8 This low CFU dose enables flexibility when formulating.

Applications

Add in mood, stress, and relaxation dietary supplements. Stack with other function-specific biotics for a robust symbiotic offering.

Women’s Health | Gut-Brain Axis | Sports Nutrition

 

 GRAS  |  Allergen-free

Interested in learning more 
about GABA PostbioticTM?

Let's Talk
Sources

 

  1. Jewett BE, Sharma S. Physiology, GABA. StatPearls. 2023.
  2. Hepsomali P, Groeger JA, Nishihira J, Scholey A. Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review. Front Neurosci 2020;14:923. https://doi.org/10.3389/fnins.2020.00923.
  3. Yamatsu A, Yamashita Y, Pandharipande T, Maru I, Kim M. Effect of oral γ-aminobutyric acid (GABA) administration on sleep and its absorption in humans. Food science and biotechnology. 2016;25(2):547-551.
  4. Yamatsu A, Yamashita Y, Maru I, Yang J, Tatsuzaki J, Kim M. The Improvement of Sleep by Oral Intake of GABA and Apocynum venetum Leaf Extract. Journal of nutritional science and vitaminology. 2015;61(2):182-187.
  5. Yoto A, Murao S, Motoki M, et al. Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks. Amino acids. 2012;43(3):1331-1337.
  6. January 2024 Tapestry New Year, New Me(ans) of Understanding Consumers; 1,442 New Years Resolutions from those aged 18-65 in the US and the UK
  7. Stress in America 2023; a nationwide survey conducted by The Harris Poll on behalf of AmericaPsychological Association among more than 3,000 U.S. adults age 18+. LINK
  8. Abdou AM, Higashiguchi S, Horie K, Kim M, Hatta H, Yokogoshi H. Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans. Biofactors. 2006;26(3):201-8.doi:10.1002/biof.5520260305