GABA Probiotic, LP815®
Stress, irritability, and sleep support
for prolonged release of GABA
Natural GABA for gut-brain modulation
GABA (Gamma-Aminobutyric Acid) is a major inhibitory neurotransmitter and functional metabolite that plays a key role in signaling the nervous system.1 Studies suggest that GABA’s main mechanism of action is to aid in slowing the stimulation of specific nerve signals in the brain, supporting mood and stress regulation.2 Deficits in GABA levels can lead to a cascade of health outcomes ranging from stress and mood swings to impacts on sleep quality. 3-5
LP815 is designed to deliver a prolonged time release of GABA to provide calming, stress, and sleep support consistently throughout the day and night.
Mental wellness is top of mind for many, and stress sits at the center of that concern. At Verb Biotics, we’re committed to making a meaningful impact, which led us to create LP815, our GABA-producing probiotic designed to support stress and sleep health.
In studies with LP815, participants reported clear, measurable results they could truly feel, including:
68%
experienced reduced stress⁶
77%
exhibited better sleep by week six6
increased & sustained
levels of urinary GABA were reported through week six6
Mechanism of Action: LP815
GABA produced in the gut can affect brain function and mood via a bidirectional communication pathway. LP815 delivers GABA through oral ingestion while working with one’s existing gut microbiota to produce additional GABA.
Prolonged GABA release: Lactiplantibacillus plantarum, LP815
Lactiplantibacillus plantarum, LP815, a proprietary strain of lactic acid bacteria, was isolated for its ability to provide sustained GABA production. By utilizing advanced computational modeling and high-throughput screening, we benchmarked against the top strains in the industry to select a superior GABA-producing psychobiotic strain.
This bacterial strain is unique for its robust and prolonged production of GABA in the gastrointestinal tract in contrast to traditional GABA supplements, which result in an immediate but transient spike in GABA levels, requiring redosing throughout the day.
Benefits of GABA Probiotic, LP8152,5, 7-8
Helps reduce feelings of irritability
Promotes a calm mood
Supports a healthy stress management
Supports deep restorative sleep
Helps reduce nighttime sweating
LP815 Clinical Substantiation
Explore the clinical publications that validate the science behind Verb Biotics’ LP815 solution. Our research demonstrates a clean commitment to proven efficacy, measurable outcomes, and a new standard of rigor in microbiome innovation.
Clinical Trial Overviews
Study #1 | Stress & Mood | Beneficial Microbes
Overview: This study assessed the impact of Lactiplantibacillus plantarum LP815 on stress.
Published in Beneficial Microbes, 2025
Read the Study
Study #2 | Sleep | MedRxIV
Overview: This study evaluated whether Lactiplantibacillus plantarum LP815 could improve sleep quality and elevate GABA levels.
Study Design: Randomized, double-blind, placebo-controlled, wearable-device clinical trial with 139 enrolled healthy adults with at least moderate difficulty falling asleep. Participants were assigned to either a placebo or 5 billion CFU of LP815 daily for 6 weeks. A small sub-cohort provided urinary samples for neurotransmitter analysis, including GABA.
Outcomes: Participants taking 5 billion CFU of LP815 experienced significant improvement in sleep quality, with 77% achieving a clinically meaningful 4-point reduction compared to 58% on placebo. Time asleep as well as deep sleep duration was significantly greater in the LP815 cohort. A sub-study shows that LP815 may increase systematic GABA levels within the first week.
Pre-print published in MedRxIV, 2025
Read the Study
From Labs to Lives: Clinical Results
Reduced Stress
Participants receiving 5 billion CFU of LP815 exhibited significantly lower GAD-7 scores at weeks 4 and 6 compared to placebo (p<0.05). 68% of participants’ GAD-7 total score improved at week 6 in the 5 billion CFU cohort, as compared to just 26% of the placebo cohort.
Those taking LP815 reduced their stress by 6.68 points, compared to 4.42 in the placebo group, reflecting a 151% greater improvement.
Improved Sleep Quality
Participants who received LP815 at the 5 billion CFU dosage exhibited significantly lower insomnia index scores at 6 weeks compared to the placebo group (p=0.02). 77.3% of participants in the LP815 cohort exhibited improvement by 4+ points at week 6.
LP815 also significantly increased sleep duration metrics (measured through the Oura Ring), showing that time in bed, total sleep, and deep sleep were significantly longer in the LP815 group compared to placebo (p<0.05).
Increased Urinary GABA Levels
Subjects who received LP815 exhibited an increase in urinary GABA compared to the placebo group during the first week of use (p<0.05) which was associated with improved sleep and reduced stress.
GABA levels increased rapidly after the first week, and were relatively stable through week 6 (p=0.04), highlighting the ability of LP815 to create a GABA factory in the gut, resulting in sustained GABA levels.
How does LP815 work?
GABA factory
The ability of LP815 to produce GABA itself can be thought of as enabling a GABA factory in the gut. This localized, sustained production supports more consistent modulation of mood, stress response, and nervous system signaling
GI performance
LP815 is derived from a natural Lactiplantibacillus plantarum strain that survives the harsh conditions of the gut to produce GABA.
Prolonged release
Unlike traditional GABA supplements which deliver a bolus dose of GABA resulting in an immediate but transient spike of GABA levels that is gone in a few hours, LP815 offers a consistent and prolonged time release of GABA, and has been studied and evaluated for its ability to provide extended and consistent stress, irritability, and sleep modulation throughout the day and night.
Lower dosage for greater application flexibility
LP815, at a dose of 5 billion CFU, produces 50mg of GABA which is the dose associated with stress, irritability, and sleep benefits.2-5, 7-8 This low CFU dose enables flexibility when formulating.
Applications
Add in mood, stress, sleep, and relaxation dietary supplements. Stack with other function-specific biotics for a robust symbiotic offering.
STRESS & MOOD | SLEEP QUALITY | GUT-BRAIN AXIS | CALMING & RELAXATION
GRAS | Allergen-free | Non-GMO | Produced in USA
Learn more the impact of psychobiotics on mental wellness
Frequently Asked Questions
What makes LP815 unique?
LP815 is function-first, not CFU-first. Most probiotics focus on colony-forming units and colonization. LP815 is designed to produce GABA, a bioactive that supports the gut-brain axis, delivering consistent, measurable effects instead of variable bacterial counts.
What makes LP815 a 'GABA-producing' probiotic?
LP815 works with existing microbes in the gut to create more GABA, acting as a “GABA factory,” delivering steady GABA to support calm mood, stress resilience, and sleep—unlike quick-spike supplements.
How does LP815 support sleep?
LP815 supports sleep by sustaining GABA levels from day to night. GABA regulates the body’s relaxation response and signals readiness for rest. By maintaining steady GABA via the gut-brain axis, LP815 promotes deeper relaxation and more consistent sleep quality over time, not just short-term effects.
Why does the body need GABA—and how does LP815 help?
Your body relies on steady GABA signaling to maintain calm, stress resilience, and balanced mood. LP815 is a GABA-producing probiotic designed to support this pathway from the gut. By helping maintain consistent GABA availability via the gut-brain axis, LP815 provides dual-action stress and sleep support.
Is LP815 clinically studied?
Yes! LP815 is supported by real-world research and peer-reviewed data on stress, mood, and sleep outcomes. LP815 is GRAS, non-GMO, and allergen-free, meeting the highest standards of safety and quality. Made in the U.S., LP815 is suitable for use in a variety of dietary supplements. Read the study in full here.
Interested in learning more about GABA Probiotic, LP815?
Sources
- Jewett BE, Sharma S. Physiology, GABA. StatPearls. 2023.
- Hepsomali P, Groeger JA, Nishihira J, Scholey A. Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review. Front Neurosci 2020;14:923. https://doi.org/10.3389/fnins.2020.00923.
- Yamatsu A, Yamashita Y, Pandharipande T, Maru I, Kim M. Effect of oral γ-aminobutyric acid (GABA) administration on sleep and its absorption in humans. Food science and biotechnology. 2016;25(2):547-551.
- Yamatsu A, Yamashita Y, Maru I, Yang J, Tatsuzaki J, Kim M. The Improvement of Sleep by Oral Intake of GABA and Apocynum venetum Leaf Extract. Journal of nutritional science and vitaminology. 2015;61(2):182-187.
- Yoto A, Murao S, Motoki M, et al. Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks. Amino acids. 2012;43(3):1331-1337.
- Grant, A.D., Erfe, M.C.B., Delebecque, C.J., Keller, D., Zimmerman, N.P., Oliver, P.L., Youssef, B., Moos, J., Luna, V., & Craft, N. (2025). Lactiplantibacillus plantarum Lp815 decreases anxiety in people with mild to moderate anxiety: a direct-to-consumer, randomised, double-blind, placebo-controlled study. Beneficial Microbes, 16(5), 521-532.
- Stress in America 2023; a nationwide survey conducted by The Harris Poll on behalf of America Psychological Association among more than 3,000 U.S. adults age 18+. LINK
- Abdou AM, Higashiguchi S, Horie K, Kim M, Hatta H, Yokogoshi H. Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans. Biofactors. 2006;26(3):201-8.doi:10.1002/biof.5520260305
Disclaimer
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