GABA for Women LP815TM

Tension and sleep support for women

for prolonged release of GABA

GABA fluctuates throughout a woman’s hormonal transition periods

A woman’s life is characterized by phases of hormonal changes, notably during the menstrual cycle and menopausal transition. These shifts in hormone levels are associated with fluctuations in GABA levels. These changing GABA levels have important implications for mood regulation, sleep, and cognition.1

77%

of women in the U.S. struggle with mental health related symptoms2

65%

of women in the U.S. struggle with stress2

52%

of women in the U.S. struggle with sleeplessness/ insomnia2

GABA levels across women’s life stages

As women age, GABA levels decrease.3 When we look closer, we find that during hormonally dynamic periods, GABA levels fluctuate.

GABA levels during Menstrual Cycle

GABA levels increase around ovulation then decrease in the premenstrual phase (both the mid luteal and the late luteal phase) which may contribute to tension, irritability, and mood swings. 1,4

GABA levels during Menopause Stages

Declining hormones from the perimenopause to post-menopausal transition can reduce GABA concentrations and may lead to sleep disturbances, tension, stress, and mood dysregulation. 5

Lactiplantibacillus plantarum LP815™, prolonged GABA effect

Lactiplantibacillus plantarum, LP815™, a proprietary strain of lactic acid bacteria, was isolated for its ability to deliver prolonged GABA through oral ingestion while working with one’s existing gut microbiota to produce additional GABA.

Benefits
of GABA for Women, LP8156,7

Tension and stress support

Helps reduce irritability

Supports deep, restorative sleep

Helps relieve night sweats

How GABA Probiotic works

GABA factory

The ability of LP815™ to produce GABA itself can be thought of as enabling a GABA factory in the gut.

GI performance

GABA Probiotic is derived from a natural Lactiplantibacillus plantarum strain that survives the harsh conditions of the gut to produce GABA.

Consistent and prolonged release

Unlike traditional GABA supplements which deliver a bolus dose of GABA resulting in an immediate but transient spike of GABA levels that is gone in a few hours, GABA Probiotic may offer a consistent and prolonged time release of GABA, providing extended and consistent emotional and sleep modulation throughout the day and night.

Lower dosage for greater application flexibility

LP815 at a dose of 5 billion CFU produces 50mg of GABA which is the dose associated with stress, mood, and sleep benefits.1 This low CFU dose enables flexibility when formulating.

Applications

Add in hormonal, premenstrual, and menopause support supplements focused on tension, mood, stress, and sleep. Stack with other function-specific biotics, botanicals, and hormone replacements for a robust symbiotic offering.

HORMONAL SUPPORT | PMS SUPPORT | MENOPAUSE SUPPORT

 

 GRAS  |  Allergen-free | Non-GMO | Produced in USA

Interested in learning more 
about GABA for women?

Let's Talk
Sources
  1. Gilfarb, R. A., & Leuner, B. (2022). GABA System Modifications During Periods of Hormonal Flux Across the Female Lifespan. Frontiers in Behavioral Neuroscience, 16, 802530. https://doi.org/10.3389/fnbeh.2022.802530.
  2. 2024 Verb Biotics Consumer Health Survey of 1,029 female consumers, US national representation
  3. Tran KH, Luki J, Hanstock S, Hanstock CC, Seres P, Aitchison K, Shandro T, Le Melledo JM. Decreased GABA+ Levels in the Medial Prefrontal Cortex of Perimenopausal Women: A 3T 1H-MRS Study. Int J Neuropsychopharmacol. 2023 Jan 19;26(1):32-41. doi: 10.1093/ijnp/pyac066. PMID: 36146906; PMCID: PMC9850658.
  4. Epperson CN, Haga K, Mason GF, Sellers E, Gueorguieva R, Zhang W, Weiss E, Rothman DL, Krystal JH. Cortical gamma-aminobutyric acid levels across the menstrual cycle in healthy women and those with premenstrual dysphoric disorder: a proton magnetic resonance spectroscopy study. Arch Gen Psychiatry. 2002 Sep;59(9):851-8. doi: 10.1001/archpsyc.59.9.851. PMID: 12215085.
  5. Wang, D., Wang, X., Luo, M., Wang, H., & Li, Y. (2019). Gamma-Aminobutyric Acid Levels in the Anterior Cingulate Cortex of Perimenopausal Women With Depression: A Magnetic Resonance Spectroscopy Study. Frontiers in Neuroscience, 13, 447833. https://doi.org/10.3389/fnins.2019.00785
  6. Grant, A.D., Erfe, M.C.B., Delebecque, C.J., Keller, D., Zimmerman, N.P., Oliver, P.L., Youssef, B., Moos, J., Luna, V., & Craft, N. (2025). Lactiplantibacillus plantarum Lp815 decreases anxiety in people with mild to moderate anxiety: a direct-to-consumer, randomised, double-blind, placebo-controlled study. Beneficial Microbes (published online ahead of print 2025). https://doi.org/10.1163/18762891-bja00073
  7. Grant, A.D., Erfe, M.C.B., Delebecque, C.J., Keller, D., Zimmerman, N.P., Kazaryan, Amy., Oliver, P.L.., Moos, J., Luna, V., & Craft, N., (2025). GABA Probiotic Lactiplantibacillus plantarum Lp815 improves sleep, anxiety and increases urinary GABA: a randomized, double-blind, placebo-controlled study. https://doi.org/10.1101/2025.04.14.25325830