Keystone Postbiotic®
for microbiome modulation, emotional wellbeing/mood, immune support, & GI relief
Strains and grains working together for foundational gut microbiome health
A healthy gut microbiome is foundational to human health
There is an intricate relationship between the gut microbiome and human health. Studies increasingly show that a diverse and well-balanced gut microbiome is crucial to our digestive health and overall wellbeing.1,2,3 When there is an imbalance in the gut microbiome, our digestive, inflammatory, and immune systems may become compromised.4
Keystone Postbiotic® is a combination of well-characterized probiotic strains fermented with oats. It promotes the growth of keystone bacteria to support a healthy gut microbiome and balanced immune response.
24000%
increase in endogenous Akkermansia while on Keystone Postbiotic 5
>50%
improvement in gas and bloating 5
Mechanisms of Action
Functional redundancy from Keystone Postbiotics’ intentionally selected ingredients delivers three synergistic mechanisms of action in the GI tract that together help support and strengthen foundational gut microbiome health.
Not a typical postbiotic: strains and oats combine for functional redundancy
Keystone Postbiotic is produced through the precision fermentation of oats using two carefully selected probiotic strains—Lactiplantibacillus and Lacticaseibacillus—chosen for their ability to work together and create health-supporting compounds. This process helps deliver targeted benefits for gut health and microbiome balance.
Microbiome benefits of Keystone Postbiotic
Promotes microbiome health
Supports production of beneficial keystone bacteria
Reduces gas and bloating
Strengthens immune performance
Supports emotional wellbeing/mood
How Does Keystone Postbiotic work?
Keystone bacteria
Keystone bacteria, such as Bifidobacteria, are important players in overall gut microbiome health. Bioactives found in Keystone Postbiotic™ increase keystone bacteria in the GI tract.
Metabolite driven
Keystone bacteria enhance the production of beneficial metabolites, such as butyrate, that have been shown to promote intestinal epithelial health and help balance digestive microflora.
Intestinal barrier integrity
Intestinal barrier integrity is paramount to a healthy gut and pivotal for a healthy immune response. Keystone Postbiotic tightens the intestinal barrier by promoting short chain fatty acid production, regulating tight junction proteins, and supporting the growth of keystone bacteria, such as Bifidobacteria that are correlated with a healthy intestinal barrier.
Immune function
Keystone Postbiotic regulates levels of cytokines that play a crucial role in our immune system education, epithelial health, and inflammation response. By modulating these cytokines, Keystone Postbiotic helps protect barrier maintenance and wound repair in times of stress, while promoting a responsible immune response.
Shelf-stable for a wider range of applications
Stability
Keystone Postbiotic is both shelf and ‘process stable’ and does not need refrigeration.
Applications
Keystone Postbiotic is heat-inactivated, making it highly versatile for use across a wide range of functional foods, beverages, and dietary supplements.
GRAS | Allergen-free | Non-GMO | Produced in USA
Frequently Asked Questions
What is a postbiotic?
A postbiotic is an inanimate microorganism that provides a health benefit to the consumer. Keystone Postbiotic uses intentionally heat-treated probiotic strains fermented with oat substrates to deliver consistent gut health benefits in a shelf-stable format.
Can postbiotics really help with bloating or digestive discomfort?
Yes! Keystone Postbiotic is designed to reduce gas and bloating by supporting gut bacteria such as Bifidobacteria. It helps to strengthen the gut barrier and supports smoother digestion — leading to greater comfort and reduced bloating.
Why would you use a heat-killed probiotic?
Heat-killed (inactivated) probiotics are stable, safe, and effective without the challenges of live strain survival. They deliver metabolic and immune benefits through their cell components and metabolites, providing consistent results in a variety of food, beverage, and supplement formats.
How does Keystone Postbiotic support gut barrier and immune health?
Keystone Postbiotic helps maintain epithelial integrity and immune balance. It promotes beneficial metabolites like butyrate, regulates cytokines, and supports keystone species that keep the gut environment healthy and resilient, which can support a stronger immune response.
Can Keystone Postbiotic be used in foods or beverages?
Yes! Keystone Postbiotic is shelf-stable and ideal for functional foods, beverages, and supplements. Its stability means brands can include it in diverse formulations without refrigeration or live strain maintenance.
Is Keystone Postbiotic safe and allergen-free?
Absolutely. Keystone Postbiotic is GRAS, allergen-free, non-GMO, and produced in the USA under rigorous quality standards.
Interested in learning more about Keystone Postbiotic?
Sources
- Foster, J. A., Rinaman, L., & Cryan, J. F. Stress & the gut-brain axis: Regulation by the microbiome. Neurobiology of Stress, 7, 124–136 (2017). https://doi.org/10.1016/j.ynstr.2017.03.001
- Wiertsema, S.P., van Bergenhenegouwen, J., Garseen, J., Knippels, L.M. The interplay between the gut microbiome and the immune system in the context of infectious diseases throughout life and the role of nutrition in optimizing treatment strategies. Nutrients, 13 (3):866 (2021). https://doi.org/10.3390/nu13030886
- Hills Jr., R., Pontefract, B., Mishcon, H., Black, C., Sutton, S., Theberge, C. Gut microbiome: profound implications for diet and disease. Nutrients, 11 (7):1613. (2021). https://doi.org/10.3390/nu11071613
- Vijay, A., Valdes, A.M. Role of the gut microbiome in chronic diseases: a narrative review. Eur J Clin Nutr 76, 489–501 (2022). https://doi.org/10.1038/s41430-021-00991-6
- Verb Biotics Human Clinical Trial 2025 n=76
- 2023 Consumer Gut Health Survey of 2,000 consumers, US national representation